Cytotoxicity of σ-Receptor Ligands Is Associated with Major Changes of Cellular Metabolism and Compl...
Cytotoxicity of σ-Receptor Ligands Is Associated with Major Changes of Cellular Metabolism and Complete Occupancy of the σ-2 Subpopulation
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United States
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English
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United States
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Tumor cells can be selectively killed by application of sigma-ligands; high concentrations (20-100 muM) are often required, however, because either diffusion barriers must be passed to reach intracellular sites or the entire sigma-receptor population should be occupied to induce cell death. We measured receptor occupancies associated with the cytot...
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Full title
Cytotoxicity of σ-Receptor Ligands Is Associated with Major Changes of Cellular Metabolism and Complete Occupancy of the σ-2 Subpopulation
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TN_cdi_pubmed_primary_18997057
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_18997057
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ISSN
0161-5505
E-ISSN
2159-662X
DOI
10.2967/jnumed.108.053876
