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Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

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Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_19050074

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

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Full title

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

Author / Creator

Kimmelman, Alec C , Hezel, Aram F , Aguirre, Andrew J , Zheng, Hongwu , Paik, Ji-hye , Ying, Haoqiang , Chu, Gerald C , Zhang, Jean X , Sahin, Ergun , Yeo, Giminna , Ponugoti, Aditya , Nabioullin, Roustem , Deroo, Scott , Yang, Shenghong , Wang, Xiaoxu , McGrath, John P , Protopopova, Marina , Ivanova, Elena , Zhang, Jianhua , Feng, Bin , Tsao, Ming S , Redston, Mark , Protopopov, Alexei , Xiao, Yonghong , Futreal, P. Andrew , Hahn, William C , Klimstra, David S , Chin, Lynda and DePinho, Ronald A

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (49), p.19372-19377

Language

English

Formats

Articles

Publication information

Publisher

United States: National Academy of Sciences

Subjects

Subjects and topics

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Scope and Contents

Contents

Pancreas ductal adenocarcinoma (PDAC) is a highly lethal cancer that typically presents as advanced, unresectable disease. This invasive tendency, coupled with intrinsic resistance to standard therapies and genome instability, are major contributors to poor long-term survival. The genetic elements governing the invasive propensity of PDAC have not...

Alternative Titles

Full title

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

Authors, Artists and Contributors

Author / Creator

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Record Identifier

TN_cdi_pubmed_primary_19050074

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_19050074

Other Identifiers

ISSN

0027-8424,1091-6490

E-ISSN

1091-6490

DOI

10.1073/pnas.0809966105

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