H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydr...
H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo
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Full title
Author / Creator
Chavan, B , Beazley, W , Wood, J M , Rokos, H , Ichinose, H and Schallreuter, K U
Publisher
United States
Journal title
Language
English
Formats
Publication information
Publisher
United States
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Scope and Contents
Contents
Patients with vitiligo accumulate up to 10(-3) mol/L concentrations of H(2)O(2) in their epidermis, which in turn affects many metabolic pathways in this compartment, including the synthesis and recycling of the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (6BH(4)). De novo synthesis of 6BH(4) is dependent on the rate-limiting enzyme GTP cyc...
Alternative Titles
Full title
H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo
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Author / Creator
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Record Identifier
TN_cdi_pubmed_primary_19101819
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_19101819
Other Identifiers
E-ISSN
1573-2665
DOI
10.1007/s10545-008-0971-1
