Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation
Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation
About this item
Full title
Author / Creator
Ma, Lei , Seager, Matthew , Wittmann, Marion , Jacobson, Marlene , Bickel, Denise , Burno, Maryann , Jones, Keith , Graufelds, Valerie Kuzmick , Xu, Guangping , Pearson, Michelle , McCampbell, Alexander , Gaspar, Renee , Shughrue, Paul , Danziger, Andrew , Regan, Christopher , Flick, Rose , Pascarella, Danette , Garson, Susan , Doran, Scott , Kreatsoulas, Constantine , Veng, Lone , Lindsley, Craig W , Shipe, William , Kuduk, Scott , Sur, Cyrille , Kinney, Gene , Seabrook, Guy R and Ray, William J
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The forebrain cholinergic system promotes higher brain function in part by signaling through the M₁ muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these cholinergic neurons degenerate, therefore selectively activating M₁ receptors could improve cognitive function in these patients while avoiding unwanted peripheral resp...
Alternative Titles
Full title
Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation
Authors, Artists and Contributors
Author / Creator
Seager, Matthew
Wittmann, Marion
Jacobson, Marlene
Bickel, Denise
Burno, Maryann
Jones, Keith
Graufelds, Valerie Kuzmick
Xu, Guangping
Pearson, Michelle
McCampbell, Alexander
Gaspar, Renee
Shughrue, Paul
Danziger, Andrew
Regan, Christopher
Flick, Rose
Pascarella, Danette
Garson, Susan
Doran, Scott
Kreatsoulas, Constantine
Veng, Lone
Lindsley, Craig W
Shipe, William
Kuduk, Scott
Sur, Cyrille
Kinney, Gene
Seabrook, Guy R
Ray, William J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_19717450
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_19717450
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0900903106
