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Alterations of the Notch pathway in lung cancer

Alterations of the Notch pathway in lung cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_20007775

Alterations of the Notch pathway in lung cancer

About this item

Full title

Alterations of the Notch pathway in lung cancer

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (52), p.22293-22298

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Notch signaling regulates cell specification and homeostasis of stem cell compartments, and it is counteracted by the cell fate determinant Numb. Both Numb and Notch have been implicated in human tumors. Here, we show that Notch signaling is altered in approximately one third of non-small-cell lung carcinomas (NSCLCs), which are the leading cause o...

Alternative Titles

Full title

Alterations of the Notch pathway in lung cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_20007775

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_20007775

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.0907781106

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