Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis
Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
pH homeostasis is essential for life, yet it remains unclear how animals sense their systemic acid/base (A/B) status. Soluble adenylyl cyclase (sAC) is an evolutionary conserved signaling enzyme that produces the second messenger cAMP in response to bicarbonate ions (HCO₃⁻). We cloned the sAC ortholog from the dogfish, a shark that regulates blood...
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Full title
Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis
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TN_cdi_pubmed_primary_20018667
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_20018667
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0911790107
