Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance
Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance
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Publisher
United States: National Acad Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Acad Sciences
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Scope and Contents
Contents
Obesity and metabolic syndrome result from excess calorie intake and genetic predisposition and are mechanistically linked to type II diabetes and accelerated body aging; abnormal nutrient and insulin signaling participate in this pathologic process, yet the underlying molecular mechanisms are incompletely understood. Mice lacking the p66 kDa isofo...
Alternative Titles
Full title
Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance
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Record Identifier
TN_cdi_pubmed_primary_20624962
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_20624962
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1008647107
