Enhanced striatal cholinergic neuronal activity mediates L-DOPA—induced dyskinesia in parkinsonian m...
Enhanced striatal cholinergic neuronal activity mediates L-DOPA—induced dyskinesia in parkinsonian mice
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Treatment of Parkinson disease (PD) with L-3,4-dihydroxyphenylalanine (L-DOPA) dramatically relieves associated motor deficits, but L-DOPA—induced dyskinesias (LID) limit the therapeutic benefit over time. Previous investigations have noted changes in striatal medium spiny neurons, including abnormal activation of extracellular signal-regulated kin...
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Full title
Enhanced striatal cholinergic neuronal activity mediates L-DOPA—induced dyskinesia in parkinsonian mice
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TN_cdi_pubmed_primary_21187382
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_21187382
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1006511108
