Optimized clinical performance of growth hormone with an expanded genetic code
Optimized clinical performance of growth hormone with an expanded genetic code
About this item
Full title
Author / Creator
Cho, Ho , Daniel, Tom , Buechler, Ying Ji , Litzinger, David C , Maio, Zhenwei , Putnam, Anna-Maria Hays , Kraynov, Vadim S , Sim, Bee-Cheng , Bussell, Stuart , Javahishvili, Tsotne , Kaphle, Sami , Viramontes, Guillermo , Ong, Mike , Chu, Stephanie , GC, Becky , Lieu, Ricky , Knudsen, Nick , Castiglioni, Paola , Norman, Thea C , Axelrod, Douglas W , Hoffman, Andrew R , Schultz, Peter G , DiMarchi, Richard D and Kimmel, Bruce E
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The ribosomal incorporation of nonnative amino acids into polypeptides in living cells provides the opportunity to endow therapeutic proteins with unique pharmacological properties. We report here the first clinical study of a biosynthetic protein produced using an expanded genetic code. Incorporation of p-acetylphenylalanine (pAcF) at distinct loc...
Alternative Titles
Full title
Optimized clinical performance of growth hormone with an expanded genetic code
Authors, Artists and Contributors
Author / Creator
Daniel, Tom
Buechler, Ying Ji
Litzinger, David C
Maio, Zhenwei
Putnam, Anna-Maria Hays
Kraynov, Vadim S
Sim, Bee-Cheng
Bussell, Stuart
Javahishvili, Tsotne
Kaphle, Sami
Viramontes, Guillermo
Ong, Mike
Chu, Stephanie
GC, Becky
Lieu, Ricky
Knudsen, Nick
Castiglioni, Paola
Norman, Thea C
Axelrod, Douglas W
Hoffman, Andrew R
Schultz, Peter G
DiMarchi, Richard D
Kimmel, Bruce E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_21576502
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_21576502
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1100387108
