Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parki...
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Parkinson disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta and the presence, in affected brain regions, of protein inclusions named Lewy bodies (LBs). The ATP13A2 gene (locus PARK9) encodes the protein ATP13A2, a lysosomal type 5 P-type...
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Full title
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
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TN_cdi_pubmed_primary_22647602
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_22647602
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1112368109
