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Acute 5-HT1A autoreceptor knockdown increases antidepressant responses and serotonin release in stre...

Acute 5-HT1A autoreceptor knockdown increases antidepressant responses and serotonin release in stre...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_22820867

Acute 5-HT1A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions

About this item

Full title

Acute 5-HT1A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions

Publisher

Berlin/Heidelberg: Springer-Verlag

Journal title

Psychopharmacology, 2013-01, Vol.225 (1), p.61-74

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer-Verlag

More information

Scope and Contents

Contents

Rationale
Identifying the etiological factors in anxiety and depression is critical to develop more efficacious therapies. The inhibitory serotonin
1A
receptors (5-HT
1A
R) located on 5-HT neurons (autoreceptors) limit antidepressant responses and their expression may be increased in treatment-resistant depressed patients.
Objecti...

Alternative Titles

Full title

Acute 5-HT1A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_22820867

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_22820867

Other Identifiers

ISSN

0033-3158

E-ISSN

1432-2072

DOI

10.1007/s00213-012-2795-9

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