Ptch1 Overexpression Drives Skin Carcinogenesis and Developmental Defects in K14Ptch Mice
Ptch1 Overexpression Drives Skin Carcinogenesis and Developmental Defects in K14Ptch Mice
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United States
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English
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United States
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Ptch1 is a key regulator of embryonic development, acting through the sonic hedgehog (SHH) signaling pathway. Ptch1 is best known as a tumor suppressor, as germline or somatic mutations in Ptch1 lead to the formation of skin basal cell carcinomas. Here we show that Ptch1 also acts as a lineage-dependent oncogene, as overexpression of Ptch1 in adult...
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Ptch1 Overexpression Drives Skin Carcinogenesis and Developmental Defects in K14Ptch Mice
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TN_cdi_pubmed_primary_23223138
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_23223138
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ISSN
0022-202X
E-ISSN
1523-1747
DOI
10.1038/jid.2012.419
