Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
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Author / Creator
Talantova, Maria , Sanz-Blasco, Sara , Zhang, Xiaofei , Xia, Peng , Akhtar, Mohd Waseem , Okamoto, Shu-ichi , Dziewczapolski, Gustavo , Nakamura, Tomohiro , Cao, Gang , Pratt, Alexander E. , Kang, Yeon-Joo , Tu, Shichun , Molokanova, Elena , McKercher, Scott R. , Hires, Samuel Andrew , Sason, Hagit , Stouffer, David G. , Buczynski, Matthew W. , Solomon, James P. , Michael, Sarah , Powers, Evan T. , Kelly, Jeffery W. , Roberts, Amanda , Tong, Gary , Fang-Newmeyer, Traci , Parker, James , Holland, Emily A. , Zhang, Dongxian , Nakanishi, Nobuki , Chen, H.-S. Vincent , Wolosker, Herman , Wang, Yuqiang , Parsons, Loren H. , Ambasudhan, Rajesh , Masliah, Eliezer , Heinemann, Stephen F. , Piña-Crespo, Juan C. and Lipton, Stuart A.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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More information
Scope and Contents
Contents
Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in Alzheimer’s disease (AD). However, the mechanism of synaptic damage remains incompletely understood. Here, using FRET-based glutamate sensor imaging, we show that amyloid-β peptide (Aβ) engages α7 nicotinic acetylcholine receptors to induce release of astrocytic gl...
Alternative Titles
Full title
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
Authors, Artists and Contributors
Author / Creator
Sanz-Blasco, Sara
Zhang, Xiaofei
Xia, Peng
Akhtar, Mohd Waseem
Okamoto, Shu-ichi
Dziewczapolski, Gustavo
Nakamura, Tomohiro
Cao, Gang
Pratt, Alexander E.
Kang, Yeon-Joo
Tu, Shichun
Molokanova, Elena
McKercher, Scott R.
Hires, Samuel Andrew
Sason, Hagit
Stouffer, David G.
Buczynski, Matthew W.
Solomon, James P.
Michael, Sarah
Powers, Evan T.
Kelly, Jeffery W.
Roberts, Amanda
Tong, Gary
Fang-Newmeyer, Traci
Parker, James
Holland, Emily A.
Zhang, Dongxian
Nakanishi, Nobuki
Chen, H.-S. Vincent
Wolosker, Herman
Wang, Yuqiang
Parsons, Loren H.
Ambasudhan, Rajesh
Masliah, Eliezer
Heinemann, Stephen F.
Piña-Crespo, Juan C.
Lipton, Stuart A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_23776240
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_23776240
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1306832110
