Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and...
Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Centrosome reorientation to the immunological synapse maintains the specificity of T-cell effector function by facilitating the directional release of cytokines and cytolytic factors toward the antigen-presenting cell. This polarization response is driven by the localized accumulation of diacylglycerol, which recruits multiple protein kinase (PK)C...
Alternative Titles
Full title
Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II
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Record Identifier
TN_cdi_pubmed_primary_23818610
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_23818610
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1306180110
