T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for e...
T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Here, we show that signals delivered by antigen engagement, IFNγ, and toll-like receptor 7 [TLR7] induce T-box transcription factor T-bet and IgG2a switching in B cells. The IgG2a product of these signals is important for viral immunity. For example, the titers of mouse gammaherpesvirus 68, an Epstein–Barr-related virus, are not well reduced if the...
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Full title
T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance
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TN_cdi_pubmed_primary_23922396
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_23922396
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1312348110
