Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants
Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The studies presented here explore the relationship between protein packing and molecular flexibility using ligand-binding cavity mutants of T4 lysozyme. Although previously reported crystal structures of the mutants investigated show single conformations that are similar to the WT protein, site-directed spin labeling in solution reveals additional...
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Full title
Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmed_primary_24167295
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_24167295
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1318754110
