Opposing role of Notch1 and Notch2 in a Kras(G12D)-driven murine non-small cell lung cancer model
Opposing role of Notch1 and Notch2 in a Kras(G12D)-driven murine non-small cell lung cancer model
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Author / Creator
Baumgart, A , Mazur, P K , Anton, M , Rudelius, M , Schwamborn, K , Feuchtinger, A , Behnke, K , Walch, A , Braren, R , Peschel, C , Duyster, J , Siveke, J T and Dechow, T
Publisher
England
Journal title
Language
English
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Publisher
England
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Contents
Lung cancer is the leading cause of cancer-related deaths worldwide. Recently, we have shown that Notch1 inhibition resulted in substantial cell death of non-small cell lung cancer (NSCLC) cells in vitro. New compounds targeting Notch signal transduction have been developed and are now being tested in clinical trials. However, the tumorigenic role...
Alternative Titles
Full title
Opposing role of Notch1 and Notch2 in a Kras(G12D)-driven murine non-small cell lung cancer model
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Record Identifier
TN_cdi_pubmed_primary_24509876
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_24509876
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E-ISSN
1476-5594
DOI
10.1038/onc.2013.592
