ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Significance Mutations in the JAK pseudokinase domain are bona fide oncogenic drivers that underlie many myeloproliferative and autoimmune diseases in humans. The JAK2 V617F mutation is responsible for ∼95% of polycythemia vera and ∼60% of primary myelofibrosis and essential thrombocytosis cases. Currently, developed JAK2 tyrosine kinase inhibitors...
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Full title
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
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TN_cdi_pubmed_primary_25825724
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_25825724
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1423201112
