Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human mac...
Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Significance A major obstacle to the eradication of HIV-1 by combination antiretroviral therapy (cART) is the formation of cellular reservoirs in CD4 ⺠T lymphocytes (carrying latently integrated provirus) and tissue macrophages. Infected macrophages assemble new virions in subcellular vacuoles known as virus-containing compartments (VCC), hiding...
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Full title
Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages
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TN_cdi_pubmed_primary_26056317
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26056317
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1500656112
