Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic...
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer
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Author / Creator
Henneman, Linda , van Miltenburg, Martine H. , Michalak, Ewa M. , Braumuller, Tanya M. , Jaspers, Janneke E. , Drenth, Anne Paulien , de Korte-Grimmerink, Renske , Gogola, Ewa , Szuhai, Karoly , Schlicker, Andreas , Ali, Rahmen Bin , Pritchard, Colin , Huijbers, Ivo J. , Berns, Anton , Rottenberg, Sven and Jonkers, Jos
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Metaplastic breast carcinoma (MBC) is a rare histological breast cancer subtype characterized by mesenchymal elements and poor clinical outcome. A large fraction of MBCs harbor defects inbreast cancer 1(BRCA1). As BRCA1 deficiency sensitizes tumors to DNA cross-linking agents and poly(ADP-ribose) polymerase (PARP) inhibitors, we sought to investiga...
Alternative Titles
Full title
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer
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Record Identifier
TN_cdi_pubmed_primary_26100884
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26100884
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1500223112
