The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation
The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation
About this item
Full title
Author / Creator
Chen, Liang , Rashid, Farooq , Shah, Abdullah , Awan, Hassaan M. , Wu, Mingming , Liu, An , Wang, Jun , Zhu, Tao , Luo, Zhaofeng and Shan, Ge
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
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Scope and Contents
Contents
p53, known as a tumor suppressor, is a DNA binding protein that regulates cell cycle, activates DNA repair proteins, and triggers apoptosis in multicellular animals. More than 50% of human cancers contain a mutation or deletion of the p53 gene, and p53R175 is one of the hot spots of p53 mutation. Nucleic acid aptamers are short singlestranded oligo...
Alternative Titles
Full title
The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_26216949
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26216949
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1502159112
