How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire
How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire
About this item
Full title
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
How T-cell receptors (TCRs) can be intrinsically biased toward MHC proteins while simultaneously display the structural adaptability required to engage diverse ligands remains a controversial puzzle. We addressed this by examining αβ TCR sequences and structures for evidence of physicochemical compatibility with MHC proteins. We found that human TC...
Alternative Titles
Full title
How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_26884163
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26884163
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1522069113
