Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegen...
Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt Q111/+ model of Huntington's disease
About this item
Full title
Author / Creator
Bragg, Robert M , Coffey, Sydney R , Weston, Rory M , Ament, Seth A , Cantle, Jeffrey P , Minnig, Shawn , Funk, Cory C , Shuttleworth, Dominic D , Woods, Emily L , Sullivan, Bonnie R , Jones, Lindsey , Glickenhaus, Anne , Anderson, John S , Anderson, Michael D , Dunnett, Stephen B , Wheeler, Vanessa C , MacDonald, Marcy E , Brooks, Simon P , Price, Nathan D and Carroll, Jeffrey B
Publisher
England
Journal title
Language
English
Formats
Publication information
Publisher
England
More information
Scope and Contents
Contents
We investigated the appearance and progression of disease-relevant signs in the B6.Htt
mouse, a genetically precise model of the mutation that causes Huntington's disease (HD). We find that B6.Htt
mice are healthy, show no overt signs of central or peripheral inflammation, and no gross motor impairment as late as 12 months of age. Behaviorall...
Alternative Titles
Full title
Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt Q111/+ model of Huntington's disease
Authors, Artists and Contributors
Author / Creator
Coffey, Sydney R
Weston, Rory M
Ament, Seth A
Cantle, Jeffrey P
Minnig, Shawn
Funk, Cory C
Shuttleworth, Dominic D
Woods, Emily L
Sullivan, Bonnie R
Jones, Lindsey
Glickenhaus, Anne
Anderson, John S
Anderson, Michael D
Dunnett, Stephen B
Wheeler, Vanessa C
MacDonald, Marcy E
Brooks, Simon P
Price, Nathan D
Carroll, Jeffrey B
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_28176805
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_28176805
Other Identifiers
E-ISSN
2045-2322
DOI
10.1038/srep41570
