Folate rescues vitamin B 12 depletion-induced inhibition of nuclear thymidylate biosynthesis and gen...
Folate rescues vitamin B 12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability
About this item
Full title
Author / Creator
Publisher
United States
Journal title
Language
English
Formats
Publication information
Publisher
United States
Subjects
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Scope and Contents
Contents
Vitamin B
12
deficiency causes hematological and neurological pathologies by impairing DNA synthesis. The nucleus is shown to be highly sensitive to 5-methyltetrahydrofolate (5-methylTHF) accumulation induced by vitamin B
12
depletion in the cytosol, leading to impaired nuclear de novo thymidylate synthesis and genome instability. These...
Alternative Titles
Full title
Folate rescues vitamin B 12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmed_primary_28461497
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_28461497
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1619582114
