Increased cathepsin S in Prdm1 -/- dendritic cells alters the T FH cell repertoire and contributes t...
Increased cathepsin S in Prdm1 -/- dendritic cells alters the T FH cell repertoire and contributes to lupus
About this item
Full title
Increased cathepsin S in Prdm1 -/- dendritic cells alters the T FH cell repertoire and contributes to lupus
Author / Creator
Publisher
United States
Journal title
Nature immunology, 2017-09, Vol.18 (9), p.1016
Language
English
Formats
Publication information
Publisher
United States
Subjects
More information
Scope and Contents
Contents
Aberrant population expansion of follicular helper T cells (T
cells) occurs in patients with lupus. An unanswered question is whether an altered repertoire of T cell antigen receptors (TCRs) is associated with such expansion. Here we found that the transcription factor Blimp-1 (encoded by Prdm1) repressed expression of the gene encoding cathepsi...
Alternative Titles
Full title
Increased cathepsin S in Prdm1 -/- dendritic cells alters the T FH cell repertoire and contributes to lupus
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_28692065
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_28692065
Other Identifiers
E-ISSN
1529-2916
DOI
10.1038/ni.3793
