α-synuclein interacts with PrP C to induce cognitive impairment through mGluR5 and NMDAR2B
α-synuclein interacts with PrP C to induce cognitive impairment through mGluR5 and NMDAR2B
About this item
Full title
α-synuclein interacts with PrP C to induce cognitive impairment through mGluR5 and NMDAR2B
Author / Creator
Publisher
United States
Journal title
Nature neuroscience, 2017-11, Vol.20 (11), p.1569
Language
English
Formats
Publication information
Publisher
United States
Subjects
More information
Scope and Contents
Contents
Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are neurodegenerative disorders that are characterized by the accumulation of α-synuclein (aSyn) in intracellular inclusions known as Lewy bodies. Prefibrillar soluble aSyn oligomers, rather than larger inclusions, are currently considered to be crucial species underlying...
Alternative Titles
Full title
α-synuclein interacts with PrP C to induce cognitive impairment through mGluR5 and NMDAR2B
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Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_28945221
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_28945221
Other Identifiers
E-ISSN
1546-1726
DOI
10.1038/nn.4648
