Promoter-bound METTL3 maintains myeloid leukaemia by m 6 A-dependent translation control
Promoter-bound METTL3 maintains myeloid leukaemia by m 6 A-dependent translation control
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Author / Creator
Barbieri, Isaia , Tzelepis, Konstantinos , Pandolfini, Luca , Shi, Junwei , Millán-Zambrano, Gonzalo , Robson, Samuel C , Aspris, Demetrios , Migliori, Valentina , Bannister, Andrew J , Han, Namshik , De Braekeleer, Etienne , Ponstingl, Hannes , Hendrick, Alan , Vakoc, Christopher R , Vassiliou, George S and Kouzarides, Tony
Publisher
England
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English
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Publisher
England
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N
-methyladenosine (m
A) is an abundant internal RNA modification in both coding and non-coding RNAs that is catalysed by the METTL3-METTL14 methyltransferase complex. However, the specific role of these enzymes in cancer is still largely unknown. Here we define a pathway that is specific for METTL3 and is implicated in the maintenance of a l...
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Full title
Promoter-bound METTL3 maintains myeloid leukaemia by m 6 A-dependent translation control
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TN_cdi_pubmed_primary_29186125
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_29186125
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E-ISSN
1476-4687
DOI
10.1038/nature24678
