Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acan...
Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin
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Basel, Switzerland: Cell Physiol Biochem Press GmbH & Co KG
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Language
English
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Basel, Switzerland: Cell Physiol Biochem Press GmbH & Co KG
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Background/Aims: The neurodegenerative disease Chorea-Acanthocytosis (ChAc) is caused by loss-of-function-mutations of the chorein-encoding gene VPS13A. In ChAc neurons transcript levels and protein abundance of Ca 2+ release activated channel moiety (CRAC) Orai1 as well as its regulator STIM1/2 are decreased, resulting in blunted store operated Ca...
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Full title
Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin
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TN_cdi_pubmed_primary_30453283
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_30453283
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ISSN
1015-8987
E-ISSN
1421-9778
DOI
10.1159/000495229
