Synthetic ligands for PreQ 1 riboswitches provide structural and mechanistic insights into targeting...
Synthetic ligands for PreQ 1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
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Publisher
England
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Language
English
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Publisher
England
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Contents
Riboswitches are naturally occurring RNA aptamers that regulate gene expression by binding to specific small molecules. Riboswitches control the expression of essential bacterial genes and are important models for RNA-small molecule recognition. Here, we report the discovery of a class of synthetic small molecules that bind to PreQ
riboswitch ap...
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Full title
Synthetic ligands for PreQ 1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
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TN_cdi_pubmed_primary_30940810
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_30940810
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E-ISSN
2041-1723
DOI
10.1038/s41467-019-09493-3
