Allosteric modulation of β-cell M 3 muscarinic acetylcholine receptors greatly improves glucose home...
Allosteric modulation of β-cell M 3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice
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Publisher
United States
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Language
English
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Publisher
United States
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Contents
Type 2 diabetes (T2D) has emerged as a major threat to human health worldwide. In T2D, pancreatic β cells are unable to release sufficient amounts of insulin to maintain physiological blood glucose levels. Acetylcholine (ACh) stimulates insulin release from mouse and human pancreatic β cells by activating a cell surface receptor known as M
3
...
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Full title
Allosteric modulation of β-cell M 3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice
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TN_cdi_pubmed_primary_31451647
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_31451647
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1904943116
