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Polarized PtdIns(4,5)P 2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sper...

Polarized PtdIns(4,5)P 2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sper...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_31776261

Polarized PtdIns(4,5)P 2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility

About this item

Full title

Polarized PtdIns(4,5)P 2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility

Publisher

United States

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (51), p.26020-26028

Language

English

Formats

Publication information

Publisher

United States

More information

Scope and Contents

Contents

Voltage-sensing phosphatase (VSP) is a unique protein that consists of both the voltage-sensor domain and phosphoinositide phosphatase domain. In contrast with intensive studies on its molecular mechanisms, its physiological role has not been clear. Here, we report that VSP plays critical roles in mouse sperm motility. We found that VSP generates a...

Alternative Titles

Full title

Polarized PtdIns(4,5)P 2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_31776261

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_31776261

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1916867116

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