Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20
Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20
About this item
Full title
Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20
Author / Creator
Publisher
United States
Journal title
Nature chemical biology, 2020-05, Vol.16 (5), p.546
Language
English
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Publication information
Publisher
United States
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Scope and Contents
Contents
The anaphase-promoting complex/cyclosome (APC/C) is a ubiquitin ligase that initiates anaphase and mitotic exit. APC/C is activated by Cdc20 and inhibited by the mitotic checkpoint complex (MCC), which delays mitotic exit when the spindle assembly checkpoint (SAC) is activated. We previously identified apcin as a small molecule ligand of Cdc20 that...
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Full title
Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20
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Record Identifier
TN_cdi_pubmed_primary_32152539
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_32152539
Other Identifiers
E-ISSN
1552-4469
DOI
10.1038/s41589-020-0495-z
