Ca 2+ -Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-c...
Ca 2+ -Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
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Publisher
England
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English
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England
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The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug-resistant enterococci. Its precise mechanism of action is incompletely understood, and a specific molecular target has not been identified. Here we show that Ca
-daptomyc...
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Full title
Ca 2+ -Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
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TN_cdi_pubmed_primary_32193379
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_32193379
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E-ISSN
2041-1723
DOI
10.1038/s41467-020-15257-1
