Pharmacological Inhibition and Activation of the Ca 2+ Activated Cl - Channel TMEM16A
Pharmacological Inhibition and Activation of the Ca 2+ Activated Cl - Channel TMEM16A
About this item
Full title
Pharmacological Inhibition and Activation of the Ca 2+ Activated Cl - Channel TMEM16A
Author / Creator
Publisher
Switzerland
Journal title
International journal of molecular sciences, 2020-04, Vol.21 (7)
Language
English
Formats
Publication information
Publisher
Switzerland
Subjects
More information
Scope and Contents
Contents
TMEM16A is a Ca
activated Cl
channel with important functions in airways, intestine, and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic fibrosis (CF) to reinstall airway Cl
secretion and to enhance airway surface liquid (ASL). This CFTR-agnostic approach is thought to improve mucociliary clearance and lun...
Alternative Titles
Full title
Pharmacological Inhibition and Activation of the Ca 2+ Activated Cl - Channel TMEM16A
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_32272686
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_32272686
Other Identifiers
E-ISSN
1422-0067
DOI
10.3390/ijms21072557
