NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2 V617F -positive myeloprolif...
NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2 V617F -positive myeloproliferative neoplasm cells
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Author / Creator
Fenerich, Bruna Alves , Fernandes, Jaqueline Cristina , Rodrigues Alves, Ana Paula Nunes , Coelho-Silva, Juan Luiz , Scopim-Ribeiro, Renata , Scheucher, Priscila Santos , Eide, Christopher A , Tognon, Cristina E , Druker, Brian J , Rego, Eduardo Magalhães , Machado-Neto, João Agostinho and Traina, Fabiola
Publisher
England
Journal title
Language
English
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Publication information
Publisher
England
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Scope and Contents
Contents
Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms (MPN); in this pathway, IRS2 is involved in the malignant transformation induced by JAK2
, and upregulation of IGF1R signaling induces the MPN phenotype. NT157, a synthetic compound designed as an IGF1R-IRS1/2 inhibit...
Alternative Titles
Full title
NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2 V617F -positive myeloproliferative neoplasm cells
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_32296029
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_32296029
Other Identifiers
E-ISSN
2059-3635
DOI
10.1038/s41392-019-0102-5
