Aberrant subchondral osteoblastic metabolism modifies Na V 1.8 for osteoarthritis
Aberrant subchondral osteoblastic metabolism modifies Na V 1.8 for osteoarthritis
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Author / Creator
Zhu, Jianxi , Zhen, Gehua , An, Senbo , Wang, Xiao , Wan, Mei , Li, Yusheng , Chen, Zhiyong , Guan, Yun , Dong, Xinzhong , Hu, Yihe and Cao, Xu
Publisher
England
Journal title
Language
English
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Publisher
England
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Contents
Pain is the most prominent symptom of osteoarthritis (OA) progression. However, the relationship between pain and OA progression remains largely unknown. Here we report osteoblast secret prostaglandin E2 (PGE2) during aberrant subchondral bone remodeling induces pain and OA progression in mice. Specific deletion of the major PGE2 producing enzyme c...
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Full title
Aberrant subchondral osteoblastic metabolism modifies Na V 1.8 for osteoarthritis
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Record Identifier
TN_cdi_pubmed_primary_32441256
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_32441256
Other Identifiers
E-ISSN
2050-084X
DOI
10.7554/eLife.57656
