Modulation of dopamine D 1 receptors via histamine H 3 receptors is a novel therapeutic target for H...
Modulation of dopamine D 1 receptors via histamine H 3 receptors is a novel therapeutic target for Huntington's disease
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Author / Creator
Moreno-Delgado, David , Puigdellívol, Mar , Moreno, Estefanía , Rodríguez-Ruiz, Mar , Botta, Joaquín , Gasperini, Paola , Chiarlone, Anna , Howell, Lesley A , Scarselli, Marco , Casadó, Vicent , Cortés, Antoni , Ferré, Sergi , Guzmán, Manuel , Lluís, Carmen , Alberch, Jordi , Canela, Enric I , Ginés, Silvia and McCormick, Peter J
Publisher
England
Journal title
Language
English
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Publication information
Publisher
England
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Scope and Contents
Contents
Early Huntington's disease (HD) include over-activation of dopamine D
receptors (D
R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D
R over-activation, we present a strategy based on targeting complexes of D
R and histamine H
receptors (H
R). Using an HD mouse striatal cell model and HD mouse...
Alternative Titles
Full title
Modulation of dopamine D 1 receptors via histamine H 3 receptors is a novel therapeutic target for Huntington's disease
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Record Identifier
TN_cdi_pubmed_primary_32513388
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_32513388
Other Identifiers
E-ISSN
2050-084X
DOI
10.7554/eLife.51093
