Molecular basis of β-arrestin coupling to formoterol-bound β 1 -adrenoceptor
Molecular basis of β-arrestin coupling to formoterol-bound β 1 -adrenoceptor
About this item
Full title
Molecular basis of β-arrestin coupling to formoterol-bound β 1 -adrenoceptor
Author / Creator
Publisher
England
Journal title
Nature (London), 2020-07, Vol.583 (7818), p.862
Language
English
Formats
Publication information
Publisher
England
Subjects
More information
Scope and Contents
Contents
The β
-adrenoceptor (β
AR) is a G-protein-coupled receptor (GPCR) that couples
to the heterotrimeric G protein G
. G-protein-mediated signalling is terminated by phosphorylation of the C terminus of the receptor by GPCR kinases (GRKs) and by coupling of β-arrestin 1 (βarr1, also known as arrestin 2), which displaces G
and induces sig...
Alternative Titles
Full title
Molecular basis of β-arrestin coupling to formoterol-bound β 1 -adrenoceptor
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_32555462
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_32555462
Other Identifiers
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2419-1
