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Voltage-independent GluN2A-type NMDA receptor Ca 2+ signaling promotes audiogenic seizures, attentio...

Voltage-independent GluN2A-type NMDA receptor Ca 2+ signaling promotes audiogenic seizures, attentio...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_33420383

Voltage-independent GluN2A-type NMDA receptor Ca 2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice

About this item

Full title

Voltage-independent GluN2A-type NMDA receptor Ca 2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice

Publisher

England

Journal title

Communications biology, 2021-01, Vol.4 (1), p.59

Language

English

Formats

Publication information

Publisher

England

More information

Scope and Contents

Contents

The NMDA receptor-mediated Ca
 signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity and thus has a key role in the nervous system. In GRIN2-variant patients alterations of this coincidence detection provoked complex clinical phenotypes, ranging from reduced muscle strength to epileptic seizur...

Alternative Titles

Full title

Voltage-independent GluN2A-type NMDA receptor Ca 2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_33420383

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_33420383

Other Identifiers

E-ISSN

2399-3642

DOI

10.1038/s42003-020-01538-4

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