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Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or prot...

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or prot...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_33574310

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

About this item

Full title

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

Publisher

England

Journal title

npj vaccines, 2020-08, Vol.5 (1), p.72

Language

English

Formats

Publication information

Publisher

England

More information

Scope and Contents

Contents

Following immunization, high-affinity antibody responses develop within germinal centers (GCs), specialized sites within follicles of the lymph node (LN) where B cells proliferate and undergo somatic hypermutation. Antigen availability within GCs is important, as B cells must acquire and present antigen to follicular helper T cells to drive this pr...

Alternative Titles

Full title

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_33574310

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_33574310

Other Identifiers

E-ISSN

2059-0105

DOI

10.1038/s41541-020-00223-1

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