Glypican-3 targeted delivery of 89 Zr and 90 Y as a theranostic radionuclide platform for hepatocell...
Glypican-3 targeted delivery of 89 Zr and 90 Y as a theranostic radionuclide platform for hepatocellular carcinoma
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Author / Creator
Publisher
England
Journal title
Language
English
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Publisher
England
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Scope and Contents
Contents
Glypican-3 (GPC3) is a tumor associated antigen expressed by hepatocellular carcinoma (HCC) cells. This preclinical study evaluated the efficacy of a theranostic platform using a GPC3-targeting antibody αGPC3 conjugated to zirconium-89 (
Zr) and yttrium-90 (
Y) to identify, treat, and assess treatment response in a murine model of HCC. A muri...
Alternative Titles
Full title
Glypican-3 targeted delivery of 89 Zr and 90 Y as a theranostic radionuclide platform for hepatocellular carcinoma
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Record Identifier
TN_cdi_pubmed_primary_33580090
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_33580090
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E-ISSN
2045-2322
DOI
10.1038/s41598-021-82172-w
