Proteolysis-targeting chimera against BCL-X L destroys tumor-infiltrating regulatory T cells
Proteolysis-targeting chimera against BCL-X L destroys tumor-infiltrating regulatory T cells
About this item
Full title
Proteolysis-targeting chimera against BCL-X L destroys tumor-infiltrating regulatory T cells
Author / Creator
Publisher
England
Journal title
Nature communications, 2021-02, Vol.12 (1), p.1281
Language
English
Formats
Publication information
Publisher
England
Subjects
More information
Scope and Contents
Contents
Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common and promotes an immunosuppressive microenvironment. Therapeutic strategies that can eliminate Tregs in the tumor (i.e., therapies that do not run the risk of affecting normal tissues), are urgently needed for the deve...
Alternative Titles
Full title
Proteolysis-targeting chimera against BCL-X L destroys tumor-infiltrating regulatory T cells
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_33627663
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_33627663
Other Identifiers
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21573-x
