Familial hypercholesterolemia class II low density lipoprotein-receptor response to statin treatment
Familial hypercholesterolemia class II low density lipoprotein-receptor response to statin treatment
About this item
Full title
Familial hypercholesterolemia class II low density lipoprotein-receptor response to statin treatment
Author / Creator
Publisher
England
Journal title
Disease models & mechanisms, 2020-01
Language
English
Formats
Publication information
Publisher
England
More information
Scope and Contents
Contents
LDL receptor (LDLR) mutations are the primary cause of familial hypercholesterolemia (FH). Class II LDLR mutations result in a misfolded LDLR retained in the endoplasmic reticulum (ER). We have developed a model of FH class II and CRISPR corrected induced pluripotent stem cells (iPSC) capable of replicating mutant and repaired LDLR functions. We sh...
Alternative Titles
Full title
Familial hypercholesterolemia class II low density lipoprotein-receptor response to statin treatment
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_34005042
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_34005042
Other Identifiers
E-ISSN
1754-8411
DOI
10.1242/dmm.042911
