Phloretin Alleviates Arsenic Trioxide-Induced Apoptosis of H9c2 Cardiomyoblasts via Downregulation i...
Phloretin Alleviates Arsenic Trioxide-Induced Apoptosis of H9c2 Cardiomyoblasts via Downregulation in Ca 2+ /Calcineurin/NFATc Pathway and Inflammatory Cytokine Release
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United States
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English
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United States
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Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs for treating acute promyelocytic leukemia patients, but its clinical use is hampered due to cardiotoxicity. The present investigation unveils the mechanism underlying ATO-induced oxidative stress that promotes calcineurin (a ubiquitous Ca
/calmodulin-dependent serine/threonine...
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Full title
Phloretin Alleviates Arsenic Trioxide-Induced Apoptosis of H9c2 Cardiomyoblasts via Downregulation in Ca 2+ /Calcineurin/NFATc Pathway and Inflammatory Cytokine Release
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TN_cdi_pubmed_primary_34037972
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_34037972
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E-ISSN
1559-0259
DOI
10.1007/s12012-021-09655-0
