TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC S75Y Cardiomyopathy
TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC S75Y Cardiomyopathy
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Switzerland
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English
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Switzerland
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A de novo missense variant in Rag GTPase protein C (RagC
) was recently identified in a syndromic dilated cardiomyopathy (DCM) patient. However, its pathogenicity and the related therapeutic strategy remain unclear. We generated a zebrafish Rragc
(corresponding to human RagC
) knock-in (KI) line via TALEN technology. The KI fish manifested...
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TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC S75Y Cardiomyopathy
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TN_cdi_pubmed_primary_34071043
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_34071043
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E-ISSN
1422-0067
DOI
10.3390/ijms22115494