Acquired Resistance to KRAS G12C Inhibition in Cancer
Acquired Resistance to KRAS G12C Inhibition in Cancer
About this item
Full title
Author / Creator
Awad, Mark M. , Liu, Shengwu , Rybkin, Igor I. , Arbour, Kathryn C. , Dilly, Julien , Zhu, Viola W. , Johnson, Melissa L. , Heist, Rebecca S. , Patil, Tejas , Riely, Gregory J. , Jacobson, Joseph O. , Yang, Xiaoping , Persky, Nicole S. , Root, David E. , Lowder, Kristen E. , Feng, Hanrong , Zhang, Shannon S. , Haigis, Kevin M. , Hung, Yin P. , Sholl, Lynette M. , Wolpin, Brian M. , Wiese, Julie , Christiansen, Jason , Lee, Jessica , Schrock, Alexa B. , Lim, Lee P. , Garg, Kavita , Li, Mark , Engstrom, Lars D. , Waters, Laura , Lawson, J. David , Olson, Peter , Lito, Piro , Ou, Sai-Hong I. , Christensen, James G. , Jänne, Pasi A. and Aguirre, Andrew J.
Publisher
United States
Journal title
Language
English
Formats
Publication information
Publisher
United States
Subjects
More information
Scope and Contents
Contents
Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at codon 12 (KRAS
). The mechanisms of acquired resistance to these therapies are currently unknown.
Among patients with
-mutant cancers treated with adagrasib monotherapy, we p...
Alternative Titles
Full title
Acquired Resistance to KRAS G12C Inhibition in Cancer
Authors, Artists and Contributors
Author / Creator
Liu, Shengwu
Rybkin, Igor I.
Arbour, Kathryn C.
Dilly, Julien
Zhu, Viola W.
Johnson, Melissa L.
Heist, Rebecca S.
Patil, Tejas
Riely, Gregory J.
Jacobson, Joseph O.
Yang, Xiaoping
Persky, Nicole S.
Root, David E.
Lowder, Kristen E.
Feng, Hanrong
Zhang, Shannon S.
Haigis, Kevin M.
Hung, Yin P.
Sholl, Lynette M.
Wolpin, Brian M.
Wiese, Julie
Christiansen, Jason
Lee, Jessica
Schrock, Alexa B.
Lim, Lee P.
Garg, Kavita
Li, Mark
Engstrom, Lars D.
Waters, Laura
Lawson, J. David
Olson, Peter
Lito, Piro
Ou, Sai-Hong I.
Christensen, James G.
Jänne, Pasi A.
Aguirre, Andrew J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_34161704
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_34161704
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa2105281
