Therapeutic high affinity T cell receptor targeting a KRAS G12D cancer neoantigen
Therapeutic high affinity T cell receptor targeting a KRAS G12D cancer neoantigen
About this item
Full title
Author / Creator
Poole, Andrew , Karuppiah, Vijaykumar , Hartt, Annabelle , Haidar, Jaafar N , Moureau, Sylvie , Dobrzycki, Tomasz , Hayes, Conor , Rowley, Christopher , Dias, Jorge , Harper, Stephen , Barnbrook, Keir , Hock, Miriam , Coles, Charlotte , Yang, Wei , Aleksic, Milos , Lin, Aimee Bence , Robinson, Ross , Dukes, Joe D , Liddy, Nathaniel , Van der Kamp, Marc , Plowman, Gregory D , Vuidepot, Annelise , Cole, David K , Whale, Andrew D and Chillakuri, Chandramouli
Publisher
England
Journal title
Language
English
Formats
Publication information
Publisher
England
Subjects
More information
Scope and Contents
Contents
Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and drives the pathogenesis of several cancers. Here we show the identification and development of an affinity-enhanced T cell receptor (TCR) that recognizes a peptide derived from the...
Alternative Titles
Full title
Therapeutic high affinity T cell receptor targeting a KRAS G12D cancer neoantigen
Authors, Artists and Contributors
Author / Creator
Karuppiah, Vijaykumar
Hartt, Annabelle
Haidar, Jaafar N
Moureau, Sylvie
Dobrzycki, Tomasz
Hayes, Conor
Rowley, Christopher
Dias, Jorge
Harper, Stephen
Barnbrook, Keir
Hock, Miriam
Coles, Charlotte
Yang, Wei
Aleksic, Milos
Lin, Aimee Bence
Robinson, Ross
Dukes, Joe D
Liddy, Nathaniel
Van der Kamp, Marc
Plowman, Gregory D
Vuidepot, Annelise
Cole, David K
Whale, Andrew D
Chillakuri, Chandramouli
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_36088370
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_36088370
Other Identifiers
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32811-1
