Optimization of the Pharmacokinetic Profile of [ 99m Tc]Tc-N 4 -Bombesin Derivatives by Modification...
Optimization of the Pharmacokinetic Profile of [ 99m Tc]Tc-N 4 -Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence
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Publisher
Switzerland
Journal title
Language
English
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Publisher
Switzerland
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Contents
Current radiolabeled gastrin-releasing peptide receptor (GRPR) ligands usually suffer from high accumulation in GRPR-positive organs (pancreas, stomach), limiting tumor-to-background contrast in the abdomen. In novel N4-bombesin derivatives this was addressed by substitutions at the Gln7-Trp8 site within the MJ9 peptide (H-Pip5-phe6-Gln7-Trp8-Ala9-...
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Full title
Optimization of the Pharmacokinetic Profile of [ 99m Tc]Tc-N 4 -Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence
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Record Identifier
TN_cdi_pubmed_primary_36145354
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_36145354
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ISSN
1424-8247
E-ISSN
1424-8247
DOI
10.3390/ph15091133
