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Phase 1 study of intraventricular 131 I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancie...

Phase 1 study of intraventricular 131 I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancie...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_36371226

Phase 1 study of intraventricular 131 I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies

About this item

Full title

Phase 1 study of intraventricular 131 I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies

Publisher

England

Journal title

Journal of hematology and oncology, 2022-11, Vol.15 (1), p.165

Language

English

Formats

Publication information

Publisher

England

More information

Scope and Contents

Contents

The prognosis for metastatic and recurrent tumors of the central nervous system (CNS) remains dismal, and the need for newer therapeutic targets and modalities is critical. The cell surface glycoprotein B7H3 is expressed on a range of solid tumors with a restricted expression on normal tissues. We hypothesized that compartmental radioimmunotherapy...

Alternative Titles

Full title

Phase 1 study of intraventricular 131 I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_36371226

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_36371226

Other Identifiers

E-ISSN

1756-8722

DOI

10.1186/s13045-022-01383-4

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