Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2 G112+5X Mutation...
Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2 G112+5X Mutation in a Guinea Pig Ventricular Myocyte Computational Model
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Switzerland
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English
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Switzerland
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Calsequestrin Type 2 (CASQ2) is a high-capacity, low-affinity, Ca
-binding protein expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 have been linked to the arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT2) that occurs with acute emotional stress or exercise can result in sudden cardia...
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Full title
Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2 G112+5X Mutation in a Guinea Pig Ventricular Myocyte Computational Model
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TN_cdi_pubmed_primary_36672764
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_36672764
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E-ISSN
2073-4425
DOI
10.3390/genes14010023
